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parkin  (Proteintech)


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    Structured Review

    Proteintech parkin
    Parkin, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 635 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+prkn/PARK2%2FParkin+Antibody/pmc13651203-101-32-36
    Average 96 stars, based on 635 article reviews
    parkin - by Bioz Stars, 2026-10
    96/100 stars

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    Related Articles

    Western Blot:

    Article Title: PRKN ‐Mediated Ubiquitin‐Proteasome Degradation of METTL3 Promotes Cellular Senescence
    Article Snippet: whole‐cell lysates were incubated overnight with the appropriate antibodies, followed by incubation with Protein A/G beads (sc‐2003, SANTA CRUZ), or anti‐Flag beads (Sigma). .. The following antibodies were used for immunoblotting: anti‐METTL3 (1:2000, ab195352, Abcam), anti‐METTL14 (1:3000, 26158‐1‐AP, Proteintech), anti‐WTAP(1:5000, 10200‐1‐AP, Proteintech), anti‐PRKN (1:1000, 14060‐1AP), anti‐p16 (1:1000, 10883‐1‐AP, Proteintech), anti‐p21 (1:1000, 2947S, CST), anti‐TRF1 (1:500, T1948, Sigma‐Aldrich), anti‐TRF2 (1:1000 dilution, 66893‐1‐IG, Proteintech), anti‐POT1 (1:500 dilution, 10581‐1‐AP, Proteintech), HRP‐conjugated goat anti‐rabbit (1:2000, 7074S, Cell Signaling Technology) or horse anti‐mouse (1:2000, 7076S, Cell Signaling Technology). .. The following antibodies were used for immunoblotting: anti‐METTL3 (1:2000, ab195352, Abcam), anti‐METTL14 (1:3000, 26158‐1‐AP, Proteintech), anti‐WTAP(1:5000, 10200‐1‐AP, Proteintech), anti‐PRKN (1:1000, 14060‐1AP), anti‐p16 (1:1000, 10883‐1‐AP, Proteintech), anti‐p21 (1:1000, 2947S, CST), anti‐TRF1 (1:500, T1948, Sigma‐Aldrich), anti‐TRF2 (1:1000 dilution, 66893‐1‐IG, Proteintech), anti‐POT1 (1:500 dilution, 10581‐1‐AP, Proteintech), HRP‐conjugated goat anti‐rabbit (1:2000, 7074S, Cell Signaling Technology) or horse anti‐mouse (1:2000, 7076S, Cell Signaling Technology).

    Article Title: PRKN-Mediated Ubiquitin-Proteasome Degradation of METTL3 Promotes Cellular Senescence.
    Article Snippet: whole- cell lysates were incubated overnight with the appropriate antibodies, followed by incubation with Protein A/G beads (sc- 2003, SANTA CRUZ), or anti- Flag beads (Sigma). .. The following antibodies were used for immunoblotting: anti- METTL3 (1:2000, ab195352, Abcam), anti- METTL14 (1:3000, 26158- 1- AP, Proteintech), anti- WTAP(1:5000, 10200- 1- AP, Proteintech), anti- PRKN (1:1000, 14060- 1AP), anti- p16 (1:1000, 10883- 1- AP, Proteintech), anti- p21 (1:1000, 2947S, CST), anti- TRF1 (1:500, T1948, Sigma- Aldrich), anti- TRF2 (1:1000 dilution, 66893- 1- IG, Proteintech), anti- POT1 (1:500 dilution, 10581- 1- AP, Proteintech), HRP- conjugated goat anti- rabbit (1:2000, 7074S, Cell Signaling Technology) or horse anti- mouse (1:2000, 7076S, Cell Signaling Technology). .. The following antibodies were used for immunoblotting: anti- METTL3 (1:2000, ab195352, Abcam), anti- METTL14 (1:3000, 26158- 1- AP, Proteintech), anti- WTAP(1:5000, 10200- 1- AP, Proteintech), anti- PRKN (1:1000, 14060- 1AP), anti- p16 (1:1000, 10883- 1- AP, Proteintech), anti- p21 (1:1000, 2947S, CST), anti- TRF1 (1:500, T1948, Sigma- Aldrich), anti- TRF2 (1:1000 dilution, 66893- 1- IG, Proteintech), anti- POT1 (1:500 dilution, 10581- 1- AP, Proteintech), HRP- conjugated goat anti- rabbit (1:2000, 7074S, Cell Signaling Technology) or horse anti- mouse (1:2000, 7076S, Cell Signaling Technology).

    Article Title: The PRKN/METTL3/CLDN2 axis promotes colorectal cancer development through epigenetic mechanisms.
    Article Snippet: .. 2 mg of protein lysates were mixed with 1 μg of anti-Flag (rabbit pAb, Cat. No. 12076-1-AP, Proteintech), anti-PRKN (Cat. No. 14060-1-AP, Proteintech), anti-METTL3 (Cat. No. 15073-1-AP, Proteintech), or isotype IgG control (Cat. No. 30000-0-AP, Proteintech) antibody overnight at 4°C, which was followed by addition of Protein A/G agarose for 3 h. Protein in the immunoprecipitates was harvested for enrichment detection of ubiquitinated METTL3, METTL3 and PRKN by immunoblot analysis. .. Evaluation of mRNA and protein stability To evaluate the impact of METTL3 or IGF2BP2 on CLDN2 mRNA stability, transfected LoVo and HCT-116 cells were maintained for 24 h in media plus actinomycin D (Act D, 50 μg/mL, Selleck).

    Control:

    Article Title: The PRKN/METTL3/CLDN2 axis promotes colorectal cancer development through epigenetic mechanisms.
    Article Snippet: .. 2 mg of protein lysates were mixed with 1 μg of anti-Flag (rabbit pAb, Cat. No. 12076-1-AP, Proteintech), anti-PRKN (Cat. No. 14060-1-AP, Proteintech), anti-METTL3 (Cat. No. 15073-1-AP, Proteintech), or isotype IgG control (Cat. No. 30000-0-AP, Proteintech) antibody overnight at 4°C, which was followed by addition of Protein A/G agarose for 3 h. Protein in the immunoprecipitates was harvested for enrichment detection of ubiquitinated METTL3, METTL3 and PRKN by immunoblot analysis. .. Evaluation of mRNA and protein stability To evaluate the impact of METTL3 or IGF2BP2 on CLDN2 mRNA stability, transfected LoVo and HCT-116 cells were maintained for 24 h in media plus actinomycin D (Act D, 50 μg/mL, Selleck).



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    ( A ) Fluorescence microscopy of Sod2 expression in zebrafish. Scale bars, 150 and 500 μm. ( B ) Confocal microscopy of <t>Park2</t> and Lc3b in zebrafish cells, focusing on the abdominal cavity near the liver. Scale bars, 5 μm. ( C ) Immunoblot analysis of Sod2, Lc3, and Park2 proteins in zebrafish. ( D ) Transmission electron microscopy of zebrafish cells near the intestine. Label 1: normal mitochondria; label 2: mitophagy process; label 3: lipid droplets; label 4: swollen mitochondria. The captured mitophagy process primarily represents the stage where lysosomes fuse with mitochondrial vesicles or mitochondrial vesicles enclose lysosomes. Scale bars, 1 and 0.5 μm. ( E to G ) Quantitative immunoblot results for Sod2, Lc3, and Park2 proteins in zebrafish. n = 3 independent biological repeats. All data are presented as the means ± SEM. Two-tailed Student’s t test; n.s., not significant; * P < 0.05; ** P < 0.01 compared with the NPC1-KO group.
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    ( A ) Fluorescence microscopy of Sod2 expression in zebrafish. Scale bars, 150 and 500 μm. ( B ) Confocal microscopy of <t>Park2</t> and Lc3b in zebrafish cells, focusing on the abdominal cavity near the liver. Scale bars, 5 μm. ( C ) Immunoblot analysis of Sod2, Lc3, and Park2 proteins in zebrafish. ( D ) Transmission electron microscopy of zebrafish cells near the intestine. Label 1: normal mitochondria; label 2: mitophagy process; label 3: lipid droplets; label 4: swollen mitochondria. The captured mitophagy process primarily represents the stage where lysosomes fuse with mitochondrial vesicles or mitochondrial vesicles enclose lysosomes. Scale bars, 1 and 0.5 μm. ( E to G ) Quantitative immunoblot results for Sod2, Lc3, and Park2 proteins in zebrafish. n = 3 independent biological repeats. All data are presented as the means ± SEM. Two-tailed Student’s t test; n.s., not significant; * P < 0.05; ** P < 0.01 compared with the NPC1-KO group.
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    ( A ) Fluorescence microscopy of Sod2 expression in zebrafish. Scale bars, 150 and 500 μm. ( B ) Confocal microscopy of <t>Park2</t> and Lc3b in zebrafish cells, focusing on the abdominal cavity near the liver. Scale bars, 5 μm. ( C ) Immunoblot analysis of Sod2, Lc3, and Park2 proteins in zebrafish. ( D ) Transmission electron microscopy of zebrafish cells near the intestine. Label 1: normal mitochondria; label 2: mitophagy process; label 3: lipid droplets; label 4: swollen mitochondria. The captured mitophagy process primarily represents the stage where lysosomes fuse with mitochondrial vesicles or mitochondrial vesicles enclose lysosomes. Scale bars, 1 and 0.5 μm. ( E to G ) Quantitative immunoblot results for Sod2, Lc3, and Park2 proteins in zebrafish. n = 3 independent biological repeats. All data are presented as the means ± SEM. Two-tailed Student’s t test; n.s., not significant; * P < 0.05; ** P < 0.01 compared with the NPC1-KO group.
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    Image Search Results


    ( A ) Fluorescence microscopy of Sod2 expression in zebrafish. Scale bars, 150 and 500 μm. ( B ) Confocal microscopy of Park2 and Lc3b in zebrafish cells, focusing on the abdominal cavity near the liver. Scale bars, 5 μm. ( C ) Immunoblot analysis of Sod2, Lc3, and Park2 proteins in zebrafish. ( D ) Transmission electron microscopy of zebrafish cells near the intestine. Label 1: normal mitochondria; label 2: mitophagy process; label 3: lipid droplets; label 4: swollen mitochondria. The captured mitophagy process primarily represents the stage where lysosomes fuse with mitochondrial vesicles or mitochondrial vesicles enclose lysosomes. Scale bars, 1 and 0.5 μm. ( E to G ) Quantitative immunoblot results for Sod2, Lc3, and Park2 proteins in zebrafish. n = 3 independent biological repeats. All data are presented as the means ± SEM. Two-tailed Student’s t test; n.s., not significant; * P < 0.05; ** P < 0.01 compared with the NPC1-KO group.

    Journal: Science Advances

    Article Title: Mito-TEMPO improves survival rates in npc1 -knockout zebrafish by reducing oxidative stress and enhancing mitophagy via Sod2

    doi: 10.1126/sciadv.aee0509

    Figure Lengend Snippet: ( A ) Fluorescence microscopy of Sod2 expression in zebrafish. Scale bars, 150 and 500 μm. ( B ) Confocal microscopy of Park2 and Lc3b in zebrafish cells, focusing on the abdominal cavity near the liver. Scale bars, 5 μm. ( C ) Immunoblot analysis of Sod2, Lc3, and Park2 proteins in zebrafish. ( D ) Transmission electron microscopy of zebrafish cells near the intestine. Label 1: normal mitochondria; label 2: mitophagy process; label 3: lipid droplets; label 4: swollen mitochondria. The captured mitophagy process primarily represents the stage where lysosomes fuse with mitochondrial vesicles or mitochondrial vesicles enclose lysosomes. Scale bars, 1 and 0.5 μm. ( E to G ) Quantitative immunoblot results for Sod2, Lc3, and Park2 proteins in zebrafish. n = 3 independent biological repeats. All data are presented as the means ± SEM. Two-tailed Student’s t test; n.s., not significant; * P < 0.05; ** P < 0.01 compared with the NPC1-KO group.

    Article Snippet: Cells were incubated with rabbit anti-mouse primary antibodies against LC3B (1:100, ABclonal, A11923), SQSTM1/p62 (1:100, ABclonal, A11483), PINK1 (1:100, ABclonal, A7131), PARK2 (1:100, ABclonal, A0968), TOMM20 (1:100, ABclonal, A6774), COX-IV (1:100, ABclonal, HB, A6564), or SOD2 (1:100, GeneTex, GTX124294) for 4 hours, followed by FITC-conjugated goat anti-rabbit IgG (1:100, Thermo Fisher Scientific, F-2765) for 1 hour at RT.

    Techniques: Fluorescence, Microscopy, Expressing, Confocal Microscopy, Western Blot, Transmission Assay, Electron Microscopy, Two Tailed Test

    ( A to F ) Flow cytometry histograms showing LC3B, p62, TOMM20, COX-IV, PINK1, and PARK2 expression in HepG2 cells. For each assay, a blank group was set without antibody but with FITC dye. ( G to L ) Statistical results for LC3B, SQSTM1/p62, TOMM20, COX-IV, PINK1, and PARK2 expression in HepG2 cells. n = 3 independent biological repeats. All data are presented as the means ± SEM. Two-tailed Student’s t test [(G) to (L)]; n.s., not significant; * P < 0.05; ** P < 0.01; *** P < 0.001 compared with the model group.

    Journal: Science Advances

    Article Title: Mito-TEMPO improves survival rates in npc1 -knockout zebrafish by reducing oxidative stress and enhancing mitophagy via Sod2

    doi: 10.1126/sciadv.aee0509

    Figure Lengend Snippet: ( A to F ) Flow cytometry histograms showing LC3B, p62, TOMM20, COX-IV, PINK1, and PARK2 expression in HepG2 cells. For each assay, a blank group was set without antibody but with FITC dye. ( G to L ) Statistical results for LC3B, SQSTM1/p62, TOMM20, COX-IV, PINK1, and PARK2 expression in HepG2 cells. n = 3 independent biological repeats. All data are presented as the means ± SEM. Two-tailed Student’s t test [(G) to (L)]; n.s., not significant; * P < 0.05; ** P < 0.01; *** P < 0.001 compared with the model group.

    Article Snippet: Cells were incubated with rabbit anti-mouse primary antibodies against LC3B (1:100, ABclonal, A11923), SQSTM1/p62 (1:100, ABclonal, A11483), PINK1 (1:100, ABclonal, A7131), PARK2 (1:100, ABclonal, A0968), TOMM20 (1:100, ABclonal, A6774), COX-IV (1:100, ABclonal, HB, A6564), or SOD2 (1:100, GeneTex, GTX124294) for 4 hours, followed by FITC-conjugated goat anti-rabbit IgG (1:100, Thermo Fisher Scientific, F-2765) for 1 hour at RT.

    Techniques: Flow Cytometry, Expressing, Two Tailed Test